Sitagliptin Tablet

Product Description

SIDE EFFECTS OF JANUVIA 50 MG TABLET 7S:

Headache, Diarrhoea, Upper Respiratory Tract Infection, Nasopharyngitis. Angioedema, Exfoliative Dermatitis, Hypoglycaemia. Potentially Fatal: Anaphylaxis And/Or Severe Dermatologic Reactions Such As Stevens-Johnson Syndrome.

DRUG INTERACTIONS OF JANUVIA 50 MG TABLET 7S:

Concurrent Use May Increase Serum Levels Of Digoxin. Increased Risk Of Hypoglycaemia When Used With Sulphonylureas.

CONTRAINDICATIONS OF JANUVIA 50 MG TABLET 7S:

Type 1 Diabetes. Diabetic Ketoacidosis.

MECHANISM OF ACTION OF JANUVIA 50 MG TABLET 7S:

Sitagliptin Inhibits Dipeptidyl Peptidase IV (DPP-IV), Resulting In Prolonged Active Incretin Levels. Incretin Hormones Increases Insulin Synthesis And Release From Pancreaticcells And Reduces Glucagon Secretion From Pancreatic Cells. Reduced Glucagon Secretion Leads To Decreased Hepatic Glucose Production. Absorption: Rapid Absorption. Bioavailability: About 87%. Distribution: Protein Binding: 38%. Metabolism: Not Extensively Metabolised. Excretion: Elimination Half-Life: 12 Hr. 87% Excreted In Urine (Mainly As Unchanged Drug) And 13% Excreted In Faeces.

SPECIAL PRECAUTIONS FOR JANUVIA 50 MG TABLET 7S:

Discontinue Treatment If There Are Signs Of Hypersensitivity. Caution When Used With Sulphonylureas And/Or Other Antidiabetic Medications; Monitor Blood Glucose Regularly. Renal Impairment; Dose Adjustment May Be Needed. Children <18 Yr. Pregnancy, Lactation.